Based on the novel by Harriet Beecher Stowe: Eliza, a slave who has a young child, pleads with Tom, another slave, to escape with her. Tom does not leave, but Eliza flees with her child. After getting some help to escape the slave traders who are looking for her, she then must try to cross the icy Ohio River if she wants to be free. Meanwhile, Tom is sold from one master to another, and his fortunes vary widely.

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