Jane McNeill attended the University of North Carolina at Chapel Hill where she studied Drama and graduated with a BA in Journalism. After 10 years in regional and Chicago theater, she earned a Masters degree in Education at DePaul University. In 2010, after surviving breast cancer, she returned to acting and has spent much of 2011 working on The Walking Dead as the character of Patricia. Subsequent film and television roles have included Prisoners, Rectify, Mississippi Grind, Magic Mike XXL, and Uncle Frank.

Filmography