Angelique Midthunder began her career in the mid-1990s by answering an ad on a whim for a casting call. After landing a leading role in a foreign film and working internationally as an actress, she consequently discovered an intrigue for the casting process. Angelique spent many successful years working in Los Angeles, and in 2005 relocated to Santa Fe, New Mexico where she quickly became one of the state's preeminent casting directors. In 2010 she was nominated alongside Richard Hicks and David Ruben for an Emmy for "Outstanding Casting for a Miniseries, Movie or a Special" for Georgia O'Keeffe - and in 2017, she was nominated alongside Jeanne McCarthy for an Aritos Award for location casting for "Captain Fantastic." Mother of Amber Midthunder, with her husband David Midthunder.

Filmography