Around 1515, Master Mathis added painted panels arranged as double wings to a sculpted altarpiece created twenty years earlier for the convent-hospital of Isenheim in Alsace. Dedicated to Saint Anthony the Abbot, the work was intended for patients afflicted by ergotism—the “St. Anthony’s fire”—a scourge of poorly nourished Europe that the Order of the Antonines sought to combat under the spiritual protection of their healing patron saint.

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