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The Substance

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Calorie Rating: 198
Released: 2024-09-07
MPAA Rating: R
Running Time: 141 Minutes
Budget: 17500000
Revenue 77316812
Homepage: https://mubi.com/en/thesubstance
Studios: Working Title Films, Blacksmith, Working Title Films,


A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Director / Directors

Matthieu de la Mortière
First Assistant Director
Anne Juin
Third Assistant Director

Clément Audebrand
Third Assistant Director
Mateo Cejoco
Third Assistant Director
Louis Tellier
Third Assistant Director

Benoit Seiller
Second Assistant Director
Marianne Huet
Script Supervisor


Cast

Demi Moore
Character: Elisabeth
Margaret Qualley
Character: Sue
Dennis Quaid
Character: Harvey

Edward Hamilton-Clark
Character: Fred
Gore Abrams
Character: Oliver
Oscar Lesage
Character: Troy

Christian Erickson
Character: Man at Diner
Robin Greer
Character: Male Nurse
Tom Morton
Character: Doctor

Hugo Diego Garcia
Character: Diego - Boyfriend
Daniel Knight
Character: Casting Director
Jonathon Carley
Character: Assistant Casting Director

Jiselle Henderkott
Character: Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
Character: TV Host
Vincent Colombe
Character: Man in Suit #1 - Harvey's Office

Billy Bentley
Character: Man in Suit #2
Lennard Ridsdale
Character: Man in Suit #3
Jordan Ford Silver
Character: Assistant Director - Pump It Up Show

Oscar Salem
Character: 2nd Assistant Director - Pump It Up Show
Viviane Bossina
Character: Sue's Assistant
Matthew Luret
Character: Floor Runner

Jana Bittnerová
Character: Maria
Olivier Raynal
Character: Alan - 2nd Agent
Tiffany Hofstetter
Character: Stylist

Nicolas Royer
Character: Guy in the Elevator
Nathan Rippy
Character: Assistant Director - New Year's Eve Show
Manon Arizmendi
Character: Little Girl - New Year's Eve Show

Virginie Kotlinski
Character: Mother - New Year's Eve Show
Brett Gillen
Character: Director of Photography - New Year's Eve Show
Charlotte Marquardt
Character: Screaming Woman

Léa Hengl
Character: Screaming Woman
Gaëlle Raymond
Character: Screaming Woman
Claire Lemaire
Character: Screaming Woman

Lila Boughoufala
Character: Screaming Woman
Aurélien Lorgnier
Character: Screaming Man
Ivan Sellier
Character: Screaming Man

Philip Schurer
Character: Screaming Man
Christian Bourmier
Character: Shareholder
Martin Graham
Character: Shareholder

Christian Bordeleau
Character: Shareholder
Patrick Hamel
Character: Shareholder
Didier Dhondt
Character: Shareholder

Jacques-Yves Dorges
Character: Shareholder
Jean-Claude Matthey
Character: Shareholder
Olivier Jarcin
Character: Shareholder

Jean-Luc Magneron
Character: Shareholder
Charlotte Murray
Character: Allison - Diner Waitress
Aaron Kahn
Character: Greeting Person

Gabriela Arnon
Character: Greeting Person
Nancy Josephson Lahoussine
Character: Greeting Person
Andrew Eldridge
Character: Greeting Person

Denise Powers
Character: Greeting Person
Bryan Jones
Character: Greeting Person
Adam Carage
Character: Happy Birthday Person

Maria McClurg
Character: Happy Birthday Person
Andrew Desmond
Character: Happy Birthday Person
Rebecca Lafont
Character: Happy Birthday Person

Laura Puech
Character: Isabella
Ryan Chidester
Character: Stagehand
Cécile Vogt
Character: Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer

Yannick Guérin
Character: Clumsy Burger Guy - Walk of Fame
Jean Miel
Character: Worker Walk of Fame
Paul Descoings
Character: Worker Walk of Fame

Benoit Lévêque
Character: Worker Walk of Fame
Arthur Molinet
Character: Cocktail Bartender
Manon Sachot
Character: Cocktail Lounge Couple

Bastien Jorelle
Character: Cocktail Lounge Couple
Kelly Hoarau
Character: Female Assistant - Towel
Michel Juskiewicz
Character: George - Harvey's Friend

Louise Greggory
Character: Restaurant Waitress
Christophe Sartirano
Character: Guy Looking at Sue
Florent Torres
Character: Guy Looking at Sue

Romain Caldeira
Character: Billboard Technician
Barthelemy Thomas
Character: Billboard Technician
Axel Baille
Character: Photographer

Ashley Lambert
Character: Additional Voices (voice)
Ranjani Brow
Character: Additional Voices (voice)
Chase Fein
Character: Additional Voices (voice)

Shane Sweet
Character: Additional Voices (voice)
William Calvert
Character: Additional Voices (voice)
Michael Corbett
Character: Additional Voices (voice)

Stephen Apostolina
Character: Additional Voices (voice)
Yann Bean
Character: The Substance (voice)
Audjyan Alcide
Character: Pump It Up Show Dancer

Jonathan Jenvrin
Character: Pump It Up Show Dancer
Mimi Maury
Character: Pump It Up Show Dancer
Amelye Solange
Character: Pump It Up Show Dancer

Kévin Table
Character: Pump It Up Show Dancer
Laura Boera
Character: Sparkle Your Life Show Dancer
Cissy Duc
Character: Sparkle Your Life Show Dancer

Sophie Mercier
Character: Sparkle Your Life Show Dancer
Marie Valton
Character: Sparkle Your Life Show Dancer
Katrina Budzynski
Character: New Year's Eve Show Dancer

Alicia Maury
Character: New Year's Eve Show Dancer
Megane Adamik
Character: New Year's Eve Show Dancer
Annalisa Pagnotta
Character: New Year's Eve Show Dancer

Maelle Dantigny
Character: New Year's Eve Show Dancer
Aleksandra Kedzierska Fontaine
Character: New Year's Eve Show Dancer
Pauline Sagetat
Character: New Year's Eve Show Dancer

Agustina Fitzsimons
Character: New Year's Eve Show Dancer
Elena Shcheglova
Character: New Year's Eve Show Dancer
Eve Marchant
Character: New Year's Eve Show Dancer

Lola Donati
Character: New Year's Eve Show Dancer
Kate Matthews
Character: New Year's Eve Show Dancer
Ophélie Jonard
Character: New Year's Eve Show Dancer

Pauline Richard
Character: New Year's Eve Show Dancer
Laureen Cappelliez
Character: New Year's Eve Show Dancer
Daria Panchenko
Character: New Year's Eve Show Dancer

Delphine Beaulieu
Character: New Year's Eve Show Dancer
Victoria Brun
Character: New Year's Eve Show Dancer
Cara Chapman
Character: New Year's Eve Show Dancer

Katharine Matthews
Character: New Year's Eve Show Dancer
Alexandra Faget
Character: New Year's Eve Show Dancer
Clémence Juville
Character: New Year's Eve Show Dancer

Margot L'Entete
Character: New Year's Eve Show Dancer
Hillary Sukhonos
Character: New Year's Eve Show Dancer
Matthew Géczy
Character: Bob Haswell (uncredited)

Namory Bakayoko
Character: Silhouette (uncredited)
Gregory Defleur
Character: Happy Birthday Person (uncredited)
Coralie Fargeat
Character: (uncredited)


Production and Crew

Erik Baiers
Executive Producer
Stanislas Reydellet
Production Design
Benjamin Kračun
Director of Photography

Cécilia Blom
Set Decoration
Frédéric Balmer
Special Effects Makeup Artist

Denise Boccacci
Prosthetic Makeup Artist
Andrea Leanza
Prosthetics Sculptor
Sebastian Lochmann
Concept Artist

Richard Martin
Prosthetics Sculptor
Krystell Morantin
Assistant Art Director
Bryan Jones
Visual Effects Supervisor

Marie Bouvet
Stunt Double
Jérôme Gaspard
Stunt Coordinator

Joffrey Darel
Stunt Driver


Chloè Acher
Second Assistant Camera

Vianne Burquier
Camera Intern
Laure Caniaux
First Assistant Camera

Benjamin Colleye
Additional First Assistant Camera
Marie-Sophie Daniel
First Assistant Camera
Steve de Rocco
Camera Operator

Charles Droudun
Electrician
Yann Festinger
Video Assist Operator
Catherine Georges
Camera Operator

Tanguy Goasguen
Additional Grip
Thomas Gros
Key Grip
Gustin Guillaume
First Assistant Camera

Stella Libert
First Assistant Camera
Nahi Margot
Electrician

Baptiste Marnière
Digital Imaging Technician
Olivier Maurin
Electrician
Jonas Poignant
Third Assistant Camera

Olivier Sargatal
Best Boy Electric
Christine Tamalet
Still Photographer

Ludovic Tobaldi
Steadicam Operator
Camille Damag
Costume Supervisor

Fabienne Menguy
Costume Supervisor
Noémie Lance
Location Manager
Nadege Marti
Location Scout

Katia Sourzac
Location Production Assistant
Baptiste Herment
Production Accountant

Benjamin Durfort
Assistant Editor

Tim Bevan
Producer

Alexandra Loewy
Executive Producer
Nicolas Royer
Executive Producer
Raffertie
Original Music Composer

Olivier Afonso
Special Effects Makeup Artist
Oriane Cattiaux
Makeup Artist
Marison De
Special Effects Makeup Artist

Sandrine Denis
Special Effects Makeup Artist
Dave Elsey
Prosthetic Supervisor
Lou Elsey
Prosthetic Supervisor

Stéphanie Guillon
Key Makeup Artist
Mélissa Jacob
Additional Hairstylist
Brian Kinney
Special Effects Makeup Artist

Lucky Nguyen
Makeup Artist
Bryony Rumble
Special Effects Makeup Artist
Cynthia Scigliuto
Makeup Artist

Julia Besnier
Production Accountant
Benjamin Celliez
Unit Production Manager

Pierre-Yves Frohard
Production Coordinator
Abraham Goldblat
Post Production Supervisor
Tiva Nagchin
Post Production Supervisor

Honorine Sutter
Assistant Production Manager
Louis Celnik
Carpenter
Marion Didier
Assistant Art Director

Amélie Meseguer
Assistant Set Decoration

Marjane Texier
Graphic Designer
Elsa Rolland
Assistant Property Master

Chloé Zobel
Property Master
Jean Miel
Special Effects Supervisor
Olaf Taittinger
Special Effects

Louis Auger
Digital Compositor
Téo L'Huillier
Digital Compositor
Guillaume Le Gouez
Visual Effects Supervisor

Louis Lion
Digital Compositor
Jacob Rogers
Digital Compositor
Guillaume Billy
Camera Trainee

Christophe Arnaud
Additional Second Assistant Camera
Thomas Burgess
Steadicam Operator

Raphaëlle Beck
Extras Casting
Aurélie Boutet
Casting Assistant
Elsa Manunta
Set Costumer

Jimmy Zhao
First Assistant Editor
Isalys Gillet
Location Assistant
Steve Sebir
Assistant Location Manager

Christophe Riso
Assistant Location Manager
Guillaume Baurez
Music Supervisor

Pierre Olivier Persin
Makeup Effects Designer

Stéphane Bécimol
Art Direction
Claire Bernengo
Boom Operator

Valérie Deloof
Sound Editor
Valérie Deloof
Sound Designer

Victor Fleurant
Sound Editor
Judah Getz
ADR Mixer
Olga Pasternak
Supervising Dialogue Editor

Margaux Peyre
Boom Operator
Thomas Pichon
Dialogue Editor
Victor Praud
Sound Re-Recording Mixer

Lucien Richardson
Supervising Dialogue Editor
Stéphane Thiébaut
Sound Re-Recording Mixer

Grégory Vincent
Foley Artist

Amélie Meseguer
Art Direction
Arnaud Denis
Art Direction

Gladys Garot
Art Direction
Julie Plumelle
Art Direction
Nathalie Vaïsse
Art Direction

Pierre Procoudine-Gorsky
Visual Effects Producer
Chevin Shafaghi
Visual Effects Supervisor
Serafin Bernfeld
Special Effects Technician

Arthur Weiser
Special Effects Technician
Marilyne Scarselli
Key Hair Stylist

Jean-Marc Benois
Additional Hairstylist
Frédérique Arguello
Key Hair Stylist